Synthesis, Characterization and Biological Activity of Novel Hg(II), Pd(II) and Cr(II) Complexes with 1,4-di-(4-fluoro-2-aminophenoxy) butane Schiff Base Derivative

Abstract

The template synthesis and characterization of several metal complexes (metal ions: Hg2+, Pd2+ and Cr2+) of macroacyclic Schiff base ligand (L) are reported. L has also been prepared from the condensation reaction of 1,4-di-(4-fluoro-2aminophenoxy)butane (DFAB) and salicylaldehyde in ethanol and characterized by IR, 1H-NMR , 13C-NMR spectroscopy and mass spectrometry. DFAB was prepared through reduction of NO2 groups of 1,4-di-(4-fluoro-2-nitrophenoxy)butane. The former compound was synthesized by nucleophilic substitution reaction (SN2) of 4-fluoro-2-nitrophenole and 1,4-dibromo butane. We are also especially interested in the antibacterial activity of these new complexes. The in vitro antibacterial activity of the metal ion, free ligand and their complexes were tested against the gram-positive bacteria; Bacillus anthracis (RTCC 1036), Staphylococcus epidermidis (PTCC 1114), Staphylococcus aureus (RTCC 1885), Enterococcus faecalis (RTCC 2121), Bacillus subtilis (PTCC 1715) and gram-negative bacteria; Pseudomonas aeruginosa (RTCC 1547), Klebsiella pneumonia (RTCC 1247), Enterobacter aerogenes (PTCC 1221), Eschericha coli (RTCC 1330) by paper disc diffusion and millidilution broth methods.